MAP kinases and the adaptive response to hypertonicity: functional preservation from yeast to mammals.
نویسندگان
چکیده
The adaptation to hypertonicity in mammalian cells is driven by multiple signaling pathways that include p38 kinase, Fyn, the catalytic subunit of PKA, ATM, and JNK2. In addition to the well-characterized tonicity enhancer (TonE)-TonE binding protein interaction, other transcription factors (and their respective cis elements) can potentially respond to hypertonicity. This review summarizes the current knowledge about the signaling pathways that regulate the adaptive response to osmotic stress and discusses new insights from yeast that could be relevant to the osmostress response in mammals.
منابع مشابه
MEKK3-mediated signaling to p38 kinase and TonE in hypertonically stressed kidney cells.
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عنوان ژورنال:
- American journal of physiology. Renal physiology
دوره 287 6 شماره
صفحات -
تاریخ انتشار 2004